Researchers Looking At Innovative Method To Treat IBD
Researchers have discovered an innovative and nontoxic treatment procedure to cure gastrointestinal issues in the human body. Gut problems like inflammatory bowel, diarrhea, and all other gastrointestinal issues have one thing in common i.e. impaired function of the intestinal epithelial barrier. Researchers have suggested that if they will tackle it then it will prevent and cure all such diseases.
The epithelial barrier is a thin tissue layer that separates intestinal lumen from the surroundings of the gut and also prevents harmful leakages. Although, it is being considered that Inflammatory Bowel Diseases (IBD) are caused due to the damages in this layer the exact reason is still unclear that what causes the impairments in it.
The team of researchers from Harvard Medical School Boston, First Affiliated Hospital of Soochow University and the University of Chicago has been aiming at Myosin Light Chain Kinase (MLCK) that can cure and prevent IBD and all other gastrointestinal issues. The enzyme, MLCK has a significant role that causes gastronomical inflammation as it directly acts and prevents such problems.
They found an appropriate molecule, Divertin which diverts the MLCK1 from the place where it acts on the epithelial layer. They tested how Diverting works on models that have IBD and diarrhea. They saw that Divertin prevented damages in the epithelial layer without hindering the work of MLCK in performing its maintenance work.
Study author of the research team, Jerrold Turner said that this discovery represents an absolutely non-toxic and novel approach in the restoration of the epithelial barrier as well as the cure of IBD.
The team also concluded that it will also be helpful in curing the barrier integrity issues like atopic dermatitis, multiple scoliosis, celiac disease, and pulmonary function. Also, it can be used for issues like hot tissue replacement in which causes GvHD (graft versus host disease).